ABSTRACT
To study the profile of atopic dermatitis in patients presenting at outpatient department of Dermatology of Isra University Hospital, Hyderabad. Observational study. This study was carried out at the Department of Dermatology, Isra UniversityHospital, Hyderabad from April 2012 to April 2014. A sample of 100 patients of atopic dermatitis was selected through non probability purposive sampling as per inclusion and exclusion criteria. Atopic dermatitis was diagnosed on the basis of patient history and clinical presentation and clinical findings. The findings were collected on a predesigned structured proforma. Written informed consent was taken from the willing participants. Ethical approval was taken from the institute. Data was analyzed on SPSS 21.0 [IBM, incorporation, USA]. Categorical variables were analyzed using chi square. P-value of statistical significance was taken at =0.05. Age range was from 1 month to 12 years. 100 patients were diagnosed with atopic dermatitis out of 5000patients with skin diseases over 2 years duration; this gives a prevalence of 2%. Onset before 10 years was note in 60% of patients. 49% showed family history of atopy. 52% were having pure atopic dermatitis, of which 85%patients showed sub acute dermatitis at presentation. While 48% showed atopic dermatitis associated with allergic rhinitis, asthma, and or both. Bacterial infection was observed in 19%, viral infection in 17%, parasitic infection in10% and fungal infection was noted in 3% of patients. Most patients were treated with a fairly simple regimen of moisturizers, topical steroids, and antibiotics for acute flares. Short courses of systemic steroids were used in 78 patients [78%]. The frequency of atopic dermatitis of present study is different to that reported in the Western literature, except for a significant and similar proportion of onset of atopic dermatitis and its clinical presentation
Subject(s)
Humans , Infant, Newborn , Child , Child, Preschool , Infant , Dermatology , Skin Diseases , Rhinitis, Allergic , Asthma , Outpatients , Hospitals, UniversityABSTRACT
The present study was conducted to investigate the prevalence of skin diseases in patients reporting at the Out Patient Department of Isra University Hospital Hyderabad. Cross sectional study. This study was carried out at Out Patient Department of Isra University Hospital Hyderabad from April 2006 - April 2014. A total of 2067 patients [1096 males and 971 females] were examined initially. Patients were selected through non probability purposive sampling as per inclusion and exclusion criteria. Because of limited time and workforce, only six dermatoses of main interest were recorded. Patients were examined by consultant dermatologist. Written informed consent was taken from the willing participants. Ethical approval was taken from the institute. Data was analyzed on SPSS 21.0 [IBM, incorporation, USA]. Categorical variables were analyzed using chi square. P-value of statistical significance was taken at =0.05. Acne vulgaris was found in girls and boys [11 to 35 years age range] with comedones being the earliest presentation. Prevalence of acne, melasma and ephelides was noted as 18%, 9.4% and 9% respectively. The prevalence of bacterial, fungal, and viral infections, scabies and head lice was observed as 9%, 9%, 3%, 9% and 8%respectively. The prevalence of eczema was 9%, atopic dermatitis 2%, seborhoiec dermatitis 2%, lichen planus 9%,vitiligo was 2%. Corns were noted in 0.6%, Alopecia areata in 0.1%, psoriasis in 0.1% and Keloids in 0.6% of the patients. Acne vulgaris was the most common skin disease while melasma and scabies were common diseases.Less prevalence was observed for the atopic dermatitis, seborhoiec dermatitis, and lichen planus. Alopecia areata,psoriasis, vitiligo and Keloids were uncommon
Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Scabies , Melanosis , Dermatitis, Atopic , Cross-Sectional Studies , Prevalence , Outpatients , Hospitals, UniversityABSTRACT
To evaluate the effect of high dose thiamine on postprandial blood glucose [PPBG] and hemoglobin A 1C levels in induced diabetic albino rat model. Experimental/Analytical study. Animal House, Isra University Hyderabad from March to October 2013. Forty adult albino rats were divided into four groups; Group I. Controls receiving normal diet, Group II. Controls receiving thiamine fortified diet, Group III. Diabetics receiving normal diet and Group IV. Diabetics receiving thiamine fortified diet. Diabetes mellitus was induced using Streptozocin. Thiamine was given at a dose of 1.6 g/kg body weight. Venous blood samples were drawn from animal's tail with a small bore cannula before and after 12 weeks of experimentation. The PPBG levels and Glycosylated HbA [HbA1c] were measured. The data was converted into database and analyzed on SPSS version 21.0 by ANOVA and Tukey-Kramer's test. A p-value of = 0.05 was taken statistically significant. The PPBG and HbA1c levels were found statistically significant in groups I vs. Ill [p=0.0001], I vs. IV [p=0.0001], II vs. Ill [p=0.0001], II vs. IV, [p=0.001] and III vs. IV [p=0.024] at 12[th] week of experimentation. The study shows significant reduction in the PPBG and HbA1c levels of rats taking thiamine compared to controls [p=0.001]. Significant differences in HbA1c levels were observed between control groups I and II vs. experimental groups III and IV [p=0.024] [p=0.0001] respectively. A highly significant difference in HbA1c was observed in rats given thiamine fortified diet compared to those not given [p=0.001]. The thiamine improves glucose metabolism in induced diabetic rat models, hence it is concluded that the thiamine may be given along with anti- diabetic drugs to overcome defects of glucose metabolism
ABSTRACT
To investigate the protective effect of Pentoxifylline [PTX] in carbon tetrachloride [CC1[4]] induced liver injury in adult male Wistar rat model. Experimental/Analytical study. Animal House, Isra University Hyderabad from May to December 2012. Forty five adult male Wistar rats were divided into three groups; Group A. controls received 0.9% isotonic saline, Group B. received CC1[4] orally [I.9mg/kg] mixed in olive oil, and Group C. received the PTX+ CC1[4]. Blood samples were collected for liver biochemical assays. The animals were sacrificed, liver tissue, after fixation in 4% formaldehyde, was embedded in paraffin. Tissue sections of 5micro thickness were subjected to haematoxylin and eosin staining and were assessed by light microscopy. The data was analyzed on SPSS 21.0 using one-way ANOVA, Tukey-Cramer and Chi-square tests. A p-value of = 0.05 was taken statistically significant. The liver biochemical and histological findings reveal statistically significant differences among the controls, CC1[4] and PTX+ CC1[4] groups [p=0.0001]. Liver enzymes and histology was deranged significantly in CC1[4] group compared to controls and PTX+ CC1[4] group [p=0.0001]. The CC1[4]+PTX group shows less elevation of liver enzymes and derangement in liver histology when compared to CC1[4] group [p=0.001]. The histological findings of congestion, inflammatory cell infiltrate, vacuolar degeneration and necrosis are found prominent in CC1[4] group. The Pentoxifylline protects against oxidative damages caused by carbon tetrachloride induced liver injury in rat model